Jul 9, 2024 · New options in late stages of clinical testing for refractory gout promise to increase the chances of reaching the guideline uric acid target with relatively modest risks for adverse events.

Apr 17, 2018 · The risk for severe cutaneous adverse reactions to allopurinol was much higher among those who were black, Asian, Native Hawaiian/Pacific Islander, women, older, or receiving higher …

May 24, 2011 · Dr. Kevin Deane discusses CONFIRMS trial data comparing the efficacy and safety of febuxostat in the treatment of hyperuricemia in gout with that of allopurinol.

Dec 12, 2024 · Usual side effects limiting use of colchicine are abdominal pain, diarrhea, nausea, and vomiting. If eGFR is less than 50 mL/min, colchicine should be used with caution at a lower dose.

Oct 22, 2012 · A study seeks to identify the optimal allopurinol dose, balancing efficacy with risk for allopurinol hypersensitivity syndrome.

Apr 17, 2001 · Question Certain textbooks/references suggest a maximum dose of allopurinol (Xyloprim, Lopurin) in patients with renal insufficiency. Presumably, this is because of renal excretion of the ...

Jun 8, 2010 · A 40-year-old gout drug has been shown to have anti-ischemic properties and could be an alternative new treatment for the symptoms of chronic stable angina, say British researchers.

May 16, 2025 · New data show that lecanemab is well tolerated outside of clinical trial setting, with expected and manageable side effects.

Dec 8, 2025 · A novel Kv7 potassium channel opener, may offer a unique treatment option for patients with resistant focal onset seizures.

Aug 12, 2025 · Excessive vitamin D intake triggers severe hypercalcemia and kidney injury in otherwise healthy individuals, highlighting the risk for unsupervised supplementation.